BDNF Extraction Viewer

📊 Дашборд — обзор экстракции BDNF

997

статей извлечено

0.13

средняя confidence

полей извлечено

4906

всего не-null значений

📋 Покрытие полей (по группам)

Идентификация (6 полей)

Поле	Заполнено	%	Ср. confidence	Пример значения
Target	387	38.8%	0.96	Neuritin 1
Alt. target	315	31.6%	0.95	BDNF
Protein family	281	28.2%	0.88	Fatty acid-binding protein family
Functional class	245	24.6%	0.86	Transcription factor
Subcellular loc.	66	6.6%	0.84	Membrane, vesicular membranes, nucleus (under amyloidogenic stress)
Isoforms (metab/obesity)	0	0.0%	0

Механизм действия (21 полей)

Поле	Заполнено	%	Ср. confidence	Пример значения
Mechanism	116	11.6%	0.93	serotonin 5-HT2A receptor agonism
Mutations (obesity/lean)	24	2.4%	0.86	Loss-of-function mutations in ADCY3 cause monogenic severe obesity
Activity (obesity)	13	1.3%	0.82	Dietary weight loss affects BDNF levels in individuals with overweight and obesi
Activity temporal	3	0.3%	0.87	Treatment administered for 30 days after 14 days of high-fat diet
Energy balance	22	2.2%	0.83	Irisin improves metabolic efficiency and is involved in metabolic adaptation; it
Appetite	11	1.1%	0.87	BDNF plays a role in appetite regulation.
Fat metabolism	11	1.1%	0.84	Enhances fat oxidation and lipolysis, preventing VAT accumulation.
Lipolysis	1	0.1%	0.90	Enhances lipolysis.
Thermogenesis	5	0.5%	0.84	Central Apolipoprotein A-IV stimulates thermogenesis in brown adipose tissue
Muscle metabolism	4	0.4%	0.91	In skeletal muscle, irisin stimulates myogenesis, enhances anabolic signaling, a
Inflammation	72	7.2%	0.88	BDNF exerts potent anti-inflammatory effects by antagonizing TLR4 on macrophages
Glucose metabolism	16	1.6%	0.85	Lowers blood glucose independently of insulin by inhibiting renal SGLT2
AA metabolism	1	0.1%	0.80	Agmatine is synthesized from L-arginine by arginine decarboxylase and can be deg
Hormonal pathways	32	3.2%	0.87	Irisin is a peptide hormone that acts as an endocrine signaling molecule in the
Cell death	52	5.2%	0.87	BDNF/TrkB signaling prevents apoptosis in hypoxic cortical neurons; inhibition o
Adipocyte fibrosis	0	0.0%	0
Upstream (biochem)	41	4.1%	0.86	HIF-1α, PI3K/AKT
Upstream (physiol)	29	2.9%	0.87	Sciatic nerve injury
Downstream (biochem)	113	11.3%	0.89	AMPK phosphorylation leads to PPARα activation, which increases BDNF expression;
Downstream (physiol)	79	7.9%	0.88	BDNF-TrkB signaling restores synaptic proteins PSD-95 and GluA1, and ameliorates
PTMs	18	1.8%	0.89	Proteolytic cleavage of FNDC5 to generate irisin.

Экспрессия (8 полей)

Поле	Заполнено	%	Ср. confidence	Пример значения
Tissue expression	210	21.1%	0.91	Hypothalamic paraventricular nucleus (PVN)
In vitro	178	17.9%	0.92	Primary microglia isolated to construct an oxygen-glucose deprivation/reoxygenat
In vivo	500	50.2%	0.93	Imipramine treatment in a rat model of Parkinson's disease induced by 6-hydroxyd
In silico	97	9.7%	0.91	Network pharmacology employed to predict active components, targets, and signali
Genetic association	111	11.1%	0.90	Case-control study of 202 CRC cases and 202 controls; rs12516 A allele associate
Ex vivo	58	5.8%	0.90	Brain tissue collection and analysis (qRT-PCR, Western blotting, immunohistochem
Animal model	516	51.8%	0.93	adult mice
Diet/model	353	35.4%	0.92	cortisol-treated neurons as in-vitro endocrine model of depression

Клиника (11 полей)

Поле	Заполнено	%	Ср. confidence	Пример значения
Drug	265	26.6%	0.97	Brexanolone
Indication	237	23.8%	0.92	Parkinson's disease
Patient subgroups	54	5.4%	0.85	Hyperlipidemic patients
Safety concerns	27	2.7%	0.90	multiregional neurotoxicity
Off-target	2	0.2%	0.80	Antioxidant, anti-inflammatory, anticancer, immunomodulation, neuroprotection
Trial stage	104	10.4%	0.88	Preclinical (in vivo rat model)
Pharma competitors	0	0.0%	0
AE severity	1	0.1%	0.90	no adverse events
MOA weight loss	8	0.8%	0.84	promotes fat oxidation
Endpoints	55	5.5%	0.89	Significant reduction in HAMD-17 scores at weeks 2 and 4; significant elevation
Approved	173	17.4%	0.87	false

📈 Распределение confidence

462

0-0.1

327

0.1-0.2

121

0.2-0.3

0.3-0.4

0.4-0.5

0.5-0.6

🏆 Топ-10 статей по confidence

PMID	Title	Confidence
41890090	Sleep deprivation impairs information processing via dysregulation of chloride homeostasis in the pr	0.59
41636883	Pharmacological inhibition of IRAK1/4 ameliorates high-fat diet-induced vascular dysfunction and cog	0.52
42001730	Mechanistic study on nonylphenol-induced depressive-like behavior: PINK1/parkin-mediated mitophagy r	0.5
42003124	Advances in Understanding Neuron-Microglia Interactions During Sciatic Nerve Injury and Regeneration	0.5
42003123	Subjects Affected by Dementia with Lewy Bodies (DLB) and Multiple System Atrophy (MSA) Elevated Brai	0.5
42003805	Synergistic Effects of Exercise and Dietary Polyphenols on Cognitive Function and Neuroprotection in	0.5
42004037	Hypothalamic thermoregulatory neurons divergently modulate isoflurane anesthesia via temperature dep	0.5
42024213	Tongqiao Huoxue Decoction (TQHXD) ameliorates ischaemic stroke in rats by promoting glycolysis enhan	0.5
42004166	Astrocytic disruption and cognitive impairment following sub-acute fentanyl administration in male r	0.5
42003111	A Network Pharmacology and Bioinformatics Approach for Determining the Mechanisms and Molecular Targ	0.5