BDNF Extraction Viewer

📊 Дашборд — обзор экстракции BDNF

997

статей извлечено

0.13

средняя confidence

полей извлечено

4906

всего не-null значений

📋 Покрытие полей (по группам)

Идентификация (6 полей)

Поле	Заполнено	%	Ср. confidence	Пример значения
Target	387	38.8%	0.96	BDNF
Alt. target	315	31.6%	0.95	BDNF
Protein family	281	28.2%	0.88	glucagon-like peptide-1 receptor agonist
Functional class	245	24.6%	0.86	Gs protein-coupled receptor
Subcellular loc.	66	6.6%	0.84	Membrane, vesicular membranes, nucleus (under amyloidogenic stress)
Isoforms (metab/obesity)	0	0.0%	0

Механизм действия (21 полей)

Поле	Заполнено	%	Ср. confidence	Пример значения
Mechanism	116	11.6%	0.93	Transcription factor regulating oxidative stress response, apoptosis, and autoph
Mutations (obesity/lean)	24	2.4%	0.86	Loss-of-function mutations in ADCY3 cause monogenic severe obesity
Activity (obesity)	13	1.3%	0.82	Decreases oxidative stress, lipid accumulation, and improves neurobehavioral def
Activity temporal	3	0.3%	0.87	Treatment for 4 weeks after 12 weeks of HFD
Energy balance	22	2.2%	0.83	MC4R is involved in energy homeostasis regulation
Appetite	11	1.1%	0.87	suppresses food intake via AgRP neuron inhibition
Fat metabolism	11	1.1%	0.84	Decreases lipid accumulation and total cholesterol; modulates fas pathway
Lipolysis	1	0.1%	0.90	Enhances lipolysis.
Thermogenesis	5	0.5%	0.84	Irisin-driven IL-33 signaling in subcutaneous adipose tissue contributes to ther
Muscle metabolism	4	0.4%	0.91	In skeletal muscle, irisin stimulates myogenesis, enhances anabolic signaling, a
Inflammation	72	7.2%	0.88	Irisin restrains inflammation in visceral adipose tissue by preserving ST2+ regu
Glucose metabolism	16	1.6%	0.85	Lowers blood glucose independently of insulin by inhibiting renal SGLT2
AA metabolism	1	0.1%	0.80	Agmatine is synthesized from L-arginine by arginine decarboxylase and can be deg
Hormonal pathways	32	3.2%	0.87	Irisin is a peptide hormone that acts as an endocrine signaling molecule in the
Cell death	52	5.2%	0.87	BDNF/TrkB signaling prevents apoptosis in hypoxic cortical neurons; inhibition o
Adipocyte fibrosis	0	0.0%	0
Upstream (biochem)	41	4.1%	0.86	Neurotrophic factors, intracellular calcium ion concentrations, carboxyl-termina
Upstream (physiol)	29	2.9%	0.87	Physical exercise; aerobic exercise
Downstream (biochem)	113	11.3%	0.89	ERK, CREB, BDNF, MAP-2, GAP-43
Downstream (physiol)	79	7.9%	0.88	BDNF-TrkB signaling restores synaptic proteins PSD-95 and GluA1, and ameliorates
PTMs	18	1.8%	0.89	Phosphorylation of PI3K, AKT, and mTOR; proteolytic cleavage of proBDNF to mBDNF

Экспрессия (8 полей)

Поле	Заполнено	%	Ср. confidence	Пример значения
Tissue expression	210	21.1%	0.91	Hypothalamic paraventricular nucleus (PVN)
In vitro	178	17.9%	0.92	Primary microglia isolated to construct an oxygen-glucose deprivation/reoxygenat
In vivo	500	50.2%	0.93	CRISPR/Cas9 and morpholino-based ints11 loss-of-function zebrafish model; pharma
In silico	97	9.7%	0.91	Network pharmacology approach using the Traditional Chinese Medicine Systems Pha
Genetic association	111	11.1%	0.90	Case-control study of 202 CRC cases and 202 controls; rs12516 A allele associate
Ex vivo	58	5.8%	0.90	Brain tissue collection and analysis (qRT-PCR, Western blotting, immunohistochem
Animal model	516	51.8%	0.93	rat
Diet/model	353	35.4%	0.92	Low and high altitude environments

Клиника (11 полей)

Поле	Заполнено	%	Ср. confidence	Пример значения
Drug	265	26.6%	0.97	Vincamine
Indication	237	23.8%	0.92	Post-stroke depression
Patient subgroups	54	5.4%	0.85	Hyperlipidemic patients
Safety concerns	27	2.7%	0.90	dose-limiting peripheral neuropathy
Off-target	2	0.2%	0.80	Antioxidant, anti-inflammatory, anticancer, immunomodulation, neuroprotection
Trial stage	104	10.4%	0.88	Preclinical (animal model)
Pharma competitors	0	0.0%	0
AE severity	1	0.1%	0.90	no adverse events
MOA weight loss	8	0.8%	0.84	induces co-expression of ERα and BDNF in the ventromedial hypothalamus via PGC-1
Endpoints	55	5.5%	0.89	Significant reduction in HAMD-17 scores at weeks 2 and 4; significant elevation
Approved	173	17.4%	0.87	true

📈 Распределение confidence

462

0-0.1

327

0.1-0.2

121

0.2-0.3

0.3-0.4

0.4-0.5

0.5-0.6

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PMID	Title	Confidence
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42003124	Advances in Understanding Neuron-Microglia Interactions During Sciatic Nerve Injury and Regeneration	0.5
42003123	Subjects Affected by Dementia with Lewy Bodies (DLB) and Multiple System Atrophy (MSA) Elevated Brai	0.5
42003805	Synergistic Effects of Exercise and Dietary Polyphenols on Cognitive Function and Neuroprotection in	0.5
42004037	Hypothalamic thermoregulatory neurons divergently modulate isoflurane anesthesia via temperature dep	0.5
42024213	Tongqiao Huoxue Decoction (TQHXD) ameliorates ischaemic stroke in rats by promoting glycolysis enhan	0.5
42004166	Astrocytic disruption and cognitive impairment following sub-acute fentanyl administration in male r	0.5
42003111	A Network Pharmacology and Bioinformatics Approach for Determining the Mechanisms and Molecular Targ	0.5