Kinetic modelling and evaluation of the TrkA/B/C radioligand [
📄 Abstract
Tropomyosin receptor kinase B (TrkB) is a critical mediator of neuronal growth, survival, and synaptic plasticity, which is activated by the endogenous ligand, brain-derived neurotrophic factor (BDNF). TrkB has been implicated in a wide range of neurological conditions, including neurodegenerative, psychiatric, and proliferative disorders. Non-invasive imaging of TrkB using positron emission tomography (PET) has been pursued to enhance understanding of its role in disease and support therapeutic development. Here, we investigated the in vitro and in vivo properties of [
Confidence:
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Идентификация (6 полей)
Target
Tropomyosin receptor kinase B
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Alt. target
TrkB
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Protein family
Tropomyosin receptor kinase
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Functional class
Receptor tyrosine kinase
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Subcellular loc.
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Isoforms (metab/obesity)
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Механизм действия (21 полей)
Mechanism
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Fat metabolism
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Lipolysis
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Inflammation
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Glucose metabolism
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AA metabolism
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Hormonal pathways
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Cell death
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Adipocyte fibrosis
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Upstream (biochem)
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Downstream (physiol)
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Экспрессия (8 полей)
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Ex vivo
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Клиника (11 полей)
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