Comparison of Morphological Signs of Neurodegenerative Changes and Expression of Neuroprotective Factors in Adult and Aged Wistar Rats in AlCl
📄 Abstract
Aluminum ions are an immunostimulating agent and a promoter of the production of ROS that play a key role in the pathogenesis of age-related diseases. The severity of morphological signs of neurodegeneration caused by chronic intake of AlCl
Confidence:
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· 3 полей извлечено
Идентификация (6 полей)
Механизм действия (21 полей)
Mechanism
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Mutations (obesity/lean)
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Activity (obesity)
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Activity temporal
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Energy balance
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Appetite
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Fat metabolism
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Lipolysis
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Thermogenesis
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Muscle metabolism
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Inflammation
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Glucose metabolism
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AA metabolism
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Hormonal pathways
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Cell death
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Adipocyte fibrosis
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Upstream (biochem)
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Upstream (physiol)
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Downstream (biochem)
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Downstream (physiol)
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PTMs
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Экспрессия (8 полей)
Tissue expression
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In vitro
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In vivo
AlCl3-induced neurodegeneration in adult and aged Wistar rats; perinatal and adult western diet exposure in rats; chronic alcohol consumption in TgF344-AD rats; aluminum chloride-induced neurotoxicity in rats; sirtuin expression in aging rat brain
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In silico
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Genetic association
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Ex vivo
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Animal model
Wistar rats; TgF344-AD rats
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Diet/model
AlCl3 exposure; western diet; chronic alcohol consumption; aluminum chloride-induced neurotoxicity
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