Sex-specific difference on anxiety- and depressive-like behavior in neuronal growth regulator 1-knockout mice.
📄 Abstract
Sex differences are evident in anxiety and depression, and women more frequently present with comorbid anxiety and depression alongside gastrointestinal disturbances. This pattern suggests contributions from sex-specific biological mechanisms and gut-brain communication. Negr1, a molecule regulating neuronal growth and connectivity, has been linked to depression-relevant behaviors in animal models. However, its mechanisms and potential sex-specific effects remain unclear. Behavioral tests were used to assess phenotypes related to depression, anxiety, and learning in male and female wild-type (WT) and Negr1 Negr1 This study demonstrates that, in Negr1
Confidence:
0.08
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Идентификация (6 полей)
Target
Negr1
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Alt. target
neuronal growth regulator 1
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Protein family
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Subcellular loc.
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Механизм действия (21 полей)
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Adipocyte fibrosis
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Экспрессия (8 полей)
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Animal model
Negr1 knockout mice
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