Hypermethylation of OPRM1: Deregulation of the Endogenous Opioid Pathway in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Fibromyalgia.
📄 Abstract
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and fibromyalgia (FM) are debilitating disorders with overlapping symptoms such as chronic pain and fatigue. Dysregulation of the endogenous opioid system, particularly µ-opioid receptor function, may contribute to their pathophysiology. This study examined whether epigenetic modifications, specifically µ-opioid receptor 1 gene (
Confidence:
0.08
· 4 полей извлечено
Идентификация (6 полей)
Target
OPRM1
0.95
Alt. target
µ-opioid receptor 1
0.95
Protein family
G protein-coupled receptor
0.80
Functional class
opioid receptor
0.90
Subcellular loc.
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Isoforms (metab/obesity)
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0.00
Механизм действия (21 полей)
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Lipolysis
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Inflammation
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Glucose metabolism
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AA metabolism
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Cell death
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Adipocyte fibrosis
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Экспрессия (8 полей)
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Клиника (11 полей)
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