Decoding BDNF in neurodevelopmental, neurodegenerative, and neurological disorders: mechanisms and therapeutic perspectives.
Confidence:
0.25
· 10 полей извлечено
Идентификация (6 полей)
Target
BDNF
1.00
Alt. target
Brain-derived neurotrophic factor
1.00
Protein family
Neurotrophin
0.90
Functional class
Growth factor
0.90
Subcellular loc.
—
0.00
Isoforms (metab/obesity)
—
0.00
Механизм действия (21 полей)
Mechanism
—
0.00
Mutations (obesity/lean)
BDNF Val66Met polymorphism; FTO rs9939609; MC4R rs17782313
0.90
Activity (obesity)
BDNF levels may be affected by dietary weight loss in overweight and obesity
0.80
Activity temporal
—
0.00
Energy balance
—
0.00
Appetite
BDNF plays a role in anorexia, bulimia, and binge-eating disorder
0.80
Fat metabolism
—
0.00
Lipolysis
—
0.00
Thermogenesis
—
0.00
Muscle metabolism
—
0.00
Inflammation
—
0.00
Glucose metabolism
—
0.00
AA metabolism
—
0.00
Hormonal pathways
—
0.00
Cell death
—
0.00
Adipocyte fibrosis
—
0.00
Upstream (biochem)
—
0.00
Upstream (physiol)
—
0.00
Downstream (biochem)
—
0.00
Downstream (physiol)
—
0.00
PTMs
—
0.00
Экспрессия (8 полей)
Tissue expression
—
0.00
In vitro
In vitro studies to investigate the potential neuroprotective and neurotransmitter modulation effects of a standardized Ginkgo biloba extract associated with phosphatidylserine
0.90
In vivo
—
0.00
In silico
—
0.00
Genetic association
—
0.00
Ex vivo
—
0.00
Animal model
rodent studies in Huntington's disease
0.80
Diet/model
dietary interventions on BDNF levels in adults
0.90