PD-L1 expression on circulating tumor cells for predicting clinical outcomes in patients with hepatocellular carcinoma receiving PD-(L)1 blockade and targeted therapy.
📄 Abstract
This study was conducted to assess the clinical significance of programmed cell death-ligand 1 (PD-L1)-positive circulating tumor cells (CTCs) as predictive biomarkers for the efficacy of PD-(L)1 inhibitor-based treatment in advanced hepatocellular carcinoma (HCC). We enrolled 59 patients with unresectable HCC who received immunotherapy-based treatment and analyzed CTCs, PD-L1 CTCs were detected in 86.4% (51/59) of patients, with a PD-L1-positive rate of 83.7% (41/49). Compared with the "PD-L1 PD-L1
Confidence:
0.12
· 6 полей извлечено
Идентификация (6 полей)
Target
PD-L1
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Alt. target
programmed cell death-ligand 1
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Protein family
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Functional class
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Subcellular loc.
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Isoforms (metab/obesity)
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Механизм действия (21 полей)
Mechanism
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Mutations (obesity/lean)
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Activity (obesity)
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Activity temporal
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Energy balance
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Appetite
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Fat metabolism
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Lipolysis
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Thermogenesis
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Muscle metabolism
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Inflammation
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Glucose metabolism
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AA metabolism
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Hormonal pathways
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Cell death
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Adipocyte fibrosis
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Upstream (biochem)
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Upstream (physiol)
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Downstream (biochem)
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Downstream (physiol)
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PTMs
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Экспрессия (8 полей)
Tissue expression
PD-L1 expression on circulating tumor cells in hepatocellular carcinoma patients
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In vitro
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In vivo
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In silico
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Genetic association
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Ex vivo
Analysis of circulating tumor cells from patients with hepatocellular carcinoma
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Animal model
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Diet/model
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Клиника (11 полей)
Drug
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Indication
hepatocellular carcinoma
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Patient subgroups
patients with PD-L1-positive circulating tumor cells
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Safety concerns
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Off-target
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Trial stage
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Pharma competitors
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AE severity
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MOA weight loss
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Endpoints
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Approved
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