6-Gingerol ameliorates high-fat, high-sucrose diet-induced metabolic dysfunction and depressive-like behaviors by attenuating neuroinflammation and oxidative stress.
📄 Abstract
High-calorie diets cause metabolic syndrome, obesity, and emotional disturbances, with neurological consequences. These prevalent conditions impair both peripheral and central nervous system function, elevating depression risk. These complications represent prevalent chronic conditions in modern society. The bioactive compound 6-gingerol demonstrates antioxidant and anti-inflammatory properties. This study investigated 6-gingerol’s protective effects against depression-like behavior and metabolic syndrome induced by a high-fat, high-sucrose diet (HFHS) in rats. Male Sprague-Dawley rats were randomly divided into six groups ( [Image: see text]
Confidence:
0.18
· 9 полей извлечено
Идентификация (6 полей)
Target
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Alt. target
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Protein family
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Functional class
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Subcellular loc.
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Isoforms (metab/obesity)
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Механизм действия (21 полей)
Mechanism
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Mutations (obesity/lean)
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Activity (obesity)
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Activity temporal
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Energy balance
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Appetite
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Fat metabolism
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Lipolysis
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Thermogenesis
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Muscle metabolism
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Inflammation
anti-inflammatory
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Glucose metabolism
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AA metabolism
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Hormonal pathways
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Cell death
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Adipocyte fibrosis
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Upstream (biochem)
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Upstream (physiol)
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Downstream (biochem)
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Downstream (physiol)
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PTMs
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Экспрессия (8 полей)
Tissue expression
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In vitro
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In vivo
6-gingerol protective effects against depression-like behavior and metabolic syndrome induced by high-fat, high-sucrose diet in rats; 6-gingerol-rich extract of ginger effects on brain oxidative stress, inflammation and neurotransmission in chronic unpredicted mild stress-induced depressed rats; high-fat diet induces depression-like behaviors in mice; dietary advanced glycation end products induced anxiety- and depression-like behaviors in female C57BL/6 mice and ameliorative effects of quercetin; effects of high-fat diet on depressive-like behavior in mice
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In silico
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Genetic association
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Ex vivo
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Animal model
Sprague-Dawley rats; Wistar rats; C57BL/6 mice; mice
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Diet/model
high-fat, high-sucrose diet (HFHS); chronic unpredicted mild stress; high-fat diet (HFD); dietary advanced glycation end products; high-fat diet
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Клиника (11 полей)
Drug
6-gingerol
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Indication
metabolic syndrome and depression
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Patient subgroups
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Safety concerns
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Off-target
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Trial stage
preclinical
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Pharma competitors
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AE severity
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MOA weight loss
attenuating neuroinflammation and oxidative stress
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Endpoints
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Approved
False
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