BBB-permeable carbon dots ameliorate Alzheimer's-like phenotypes in mice by suppressing oxidative stress, neuroinflammation, and amyloid-β aggregation.
📄 Abstract
Alzheimer's disease (AD) is a common neurodegenerative disorder wherein reactive oxygen species (ROS) and Amyloid-β-protein (Aβ) play critical roles. Inspired by traditional Chinese charcoal drug and the anti-inflammatory properties of some carbon dots, we developed Radix Isatidis derived carbon dots (RI-CDs) via a hydrothermal method. The RI-CDs can cross the blood-brain barrier (BBB) and were thus evaluated for AD therapy. In vitro, RI-CDs scavenged ROS, inhibited Aβ
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Идентификация (6 полей)
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Механизм действия (21 полей)
Экспрессия (8 полей)
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In vitro
RI-CDs scavenged ROS, inhibited Aβ aggregation
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In vivo
RI-CDs evaluated for AD therapy in mice; ameliorated Alzheimer's-like phenotypes
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mice
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Alzheimer's disease model
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Клиника (11 полей)
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