BDNF and NLRP3 signaling differentially regulate formation and retrieval of nitrous oxide (N
📄 Abstract
The formation and retrieval of reward memories within the hippocampus are critical mechanisms underlying the development of substance use disorder. Nitrous oxide (N
Confidence:
0.07
· 4 полей извлечено
Идентификация (6 полей)
Target
BDNF
0.90
Alt. target
Brain-Derived Neurotrophic Factor
0.90
Protein family
Neurotrophin family
0.80
Functional class
Growth factor
0.80
Subcellular loc.
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0.00
Isoforms (metab/obesity)
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0.00
Механизм действия (21 полей)
Mechanism
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Mutations (obesity/lean)
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Activity (obesity)
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Activity temporal
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Energy balance
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Appetite
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0.00
Fat metabolism
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0.00
Lipolysis
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0.00
Thermogenesis
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0.00
Muscle metabolism
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0.00
Inflammation
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0.00
Glucose metabolism
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0.00
AA metabolism
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0.00
Hormonal pathways
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0.00
Cell death
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0.00
Adipocyte fibrosis
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0.00
Upstream (biochem)
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0.00
Upstream (physiol)
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0.00
Downstream (biochem)
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0.00
Downstream (physiol)
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0.00
PTMs
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0.00
Экспрессия (8 полей)
Tissue expression
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In vitro
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In vivo
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In silico
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Genetic association
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Ex vivo
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Animal model
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Diet/model
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Клиника (11 полей)
Drug
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Indication
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Patient subgroups
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Safety concerns
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Off-target
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Trial stage
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Pharma competitors
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AE severity
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0.00
MOA weight loss
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0.00
Endpoints
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0.00
Approved
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