Mitochondrial calcium uniporter knockdown in hippocampal neurons effectively attenuates synaptic plasticity impairment and pathology in APP/PS1/tau model of Alzheimer's disease.
📄 Abstract
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive cognitive decline, in which mitochondrial dysfunction plays a critical role. The mitochondrial calcium uniporter (MCU) is a key regulator of mitochondrial calcium (mCa
Confidence:
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Идентификация (6 полей)
Target
Mitochondrial calcium uniporter
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Alt. target
MCU
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Protein family
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Subcellular loc.
Mitochondria
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Механизм действия (21 полей)
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AA metabolism
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Cell death
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Adipocyte fibrosis
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Экспрессия (8 полей)
Tissue expression
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In vitro
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In vivo
APP/PS1/tau mouse model of Alzheimer's disease
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In silico
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Ex vivo
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Animal model
APP/PS1/tau mouse model
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