Enhanced central histaminergic transmission via H
📄 Abstract
The role of central histamine in diabetes induced behavioral despair is still an enigma. Therefore, the current research explored the plausible impact of the central histaminergic activity on the expression of diabetes-induced behavioral despair in mice using the tail suspension test (TST) and surose preference test (SPT) along with changes in the levels of BDNF and phosphorylated CREB (pCREB) in the whole brain, hippocampus, PFC, and amygdala. Post-streptozotocin (STZ) (200 mg/kg, i.p.) injection, on the 4
Confidence:
0.08
· 3 полей извлечено
Идентификация (6 полей)
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Механизм действия (21 полей)
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Экспрессия (8 полей)
Tissue expression
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In vivo
The study explored the impact of central histaminergic activity on diabetes-induced behavioral despair in mice using tail suspension test and sucrose preference test, with measurements of BDNF and pCREB in brain regions.
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Animal model
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Diet/model
Streptozotocin-induced diabetes
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