Upstream CB1R Regulation of β-Adrenergic Memory Consolidation.
📄 Abstract
Object recognition memory (ORM) plays a key role in identifying familiar items and encoding episodic information. ORM consolidation depends on β-adrenergic receptor (βAR) signaling and is associated with increased BDNF expression in the dorsal hippocampus. Although hippocampal activation of cannabinoid type-1 receptors (CB1Rs) is known to impair ORM consolidation, the mechanisms underlying this effect remain unclear. In this study, we used the novel object recognition task to examine the interaction between CB1Rs and βARs during ORM consolidation in adult male Wistar rats. Intra-dorsal CA1 infusion of the CB1R agonist ACEA, the βAR antagonist propranolol, or the PKA inhibitor myristoylated PKI
Confidence:
0.29
· 15 полей извлечено
Идентификация (6 полей)
Target
cannabinoid type-1 receptor
0.95
Alt. target
CB1R
0.95
Protein family
G protein-coupled receptor
0.90
Functional class
receptor
0.90
Subcellular loc.
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0.00
Isoforms (metab/obesity)
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0.00
Механизм действия (21 полей)
Mechanism
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0.00
Mutations (obesity/lean)
MC4R mutation
0.90
Activity (obesity)
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0.00
Activity temporal
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0.00
Energy balance
MC4R is central to the regulation of energy homeostasis
0.90
Appetite
MC4R is central to the regulation of appetite; hypothalamic leptin-melanocortin pathway regulates appetite
0.90
Fat metabolism
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0.00
Lipolysis
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0.00
Thermogenesis
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0.00
Muscle metabolism
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0.00
Inflammation
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0.00
Glucose metabolism
MC4R regulates glucose homeostasis through adrenaline-mediated control of glucose reabsorption via renal GLUT2
0.90
AA metabolism
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0.00
Hormonal pathways
MC4R facilitates hypothalamic-pituitary-adrenocortical (HPA) axis responses to acute stress; hypothalamic leptin-melanocortin pathway is central to regulation; leptin activates the proopiomelanocortin pathway
0.90
Cell death
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0.00
Adipocyte fibrosis
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0.00
Upstream (biochem)
Leptin, Endogenous cannabinoids
0.90
Upstream (physiol)
Stress
0.80
Downstream (biochem)
Adrenaline
0.90
Downstream (physiol)
HPA axis, Glucose reabsorption
0.90
PTMs
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0.00
Экспрессия (8 полей)
Tissue expression
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0.00
In vitro
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0.00
In vivo
Intra-dorsal CA1 infusion of CB1R agonist ACEA, βAR antagonist propranolol, or PKA inhibitor myristoylated PKI in adult male Wistar rats during novel object recognition task
0.90
In silico
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0.00
Genetic association
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0.00
Ex vivo
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0.00
Animal model
Adult male Wistar rats
0.90
Diet/model
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0.00
Клиника (11 полей)
Drug
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0.00
Indication
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Patient subgroups
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0.00
Safety concerns
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0.00
Off-target
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0.00
Trial stage
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0.00
Pharma competitors
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0.00
AE severity
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0.00
MOA weight loss
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0.00
Endpoints
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0.00
Approved
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0.00