BDNF Val66Met protects oxaliplatin-induced peripheral neuropathy in patients with colorectal cancer.
📄 Abstract
Chemotherapy-induced peripheral neuropathy (CIPN) remains a major unmet challenge in oncology, affecting treatment adherence and patient quality of life. Despite its prevalence, reliable predictive biomarkers and targeted neuroprotective strategies remain elusive. This study integrates clinical data, whole-genome sequencing, and translational research to identify genetic determinants of CIPN susceptibility and validate therapeutic approaches. Through comprehensive analysis of patients with colorectal cancer, including neurophysiological evaluations and CIPN-specific quality-of-life assessments, we identified the
Confidence:
0.13
· 7 полей извлечено
Идентификация (6 полей)
Target
BDNF
0.95
Alt. target
Brain-Derived Neurotrophic Factor
0.90
Protein family
neurotrophin
0.80
Functional class
growth factor
0.80
Subcellular loc.
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Isoforms (metab/obesity)
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0.00
Механизм действия (21 полей)
Mechanism
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Mutations (obesity/lean)
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Activity (obesity)
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Activity temporal
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Energy balance
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Appetite
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Fat metabolism
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Lipolysis
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Thermogenesis
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Muscle metabolism
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Inflammation
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Glucose metabolism
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AA metabolism
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Hormonal pathways
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Cell death
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Adipocyte fibrosis
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Upstream (biochem)
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Upstream (physiol)
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Downstream (biochem)
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Downstream (physiol)
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PTMs
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Экспрессия (8 полей)
Tissue expression
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In vitro
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In vivo
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In silico
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Genetic association
BDNF Val66Met polymorphism associated with protection against oxaliplatin-induced peripheral neuropathy in colorectal cancer patients; BDNF rs6265 polymorphism associated with severe cancer-related fatigue and neuropathic pain in female cancer survivors
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Ex vivo
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Animal model
Rat model of paclitaxel-induced peripheral neuropathy
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Diet/model
Selenium supplementation in paclitaxel-induced peripheral neuropathy rat model
0.90
Клиника (11 полей)
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Indication
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Off-target
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Trial stage
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Pharma competitors
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AE severity
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MOA weight loss
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Approved
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