Cannabidiol-rich extract suppresses the activation of proinflammatory genes IL-1β and IL-6 in equine mesenchymal stem cells stimulated with lipopolysaccharide.
📄 Abstract
Peripheral nerve injuries (PNI) often lead to long-term functional impairment. Mesenchymal stem cells (MSCs) and cannabidiol (CBD) have shown anti-inflammatory and neuroprotective effects in vitro, which may be relevant for PNI research. The aim of this study was to evaluate CBD-rich cannabis extract’s potential to induce anti-inflammatory and neurotrophic gene expression in equine adipose tissue-derived MSCs (EqAT-MSCs) in an inflammatory in vitro environment. The morphology and metabolic activity of EqAT-MSCs (
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Идентификация (6 полей)
Механизм действия (21 полей)
Mechanism
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Экспрессия (8 полей)
Tissue expression
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In vitro
equine adipose tissue-derived mesenchymal stem cells (EqAT-MSCs) stimulated with lipopolysaccharide
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Клиника (11 полей)
Drug
cannabidiol
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