Synthesis and biological evaluation of novel naphthoquinone [2,3-d] thiazole derivatives as potent 17β-HSD10 inhibitor.
📄 Abstract
A series of novel naphthoquinone[2,3-d] thiazole derivatives were designed as 17β-HSD10 inhibitors. Compound 14 emerged as the lead candidate, demonstrating potent 17β-HSD10 inhibition (IC
Confidence:
0.25
· 4 полей извлечено
Идентификация (6 полей)
Target
17β-HSD10
0.95
Alt. target
—
0.00
Protein family
17β-hydroxysteroid dehydrogenase
0.90
Functional class
oxidoreductase
0.80
Subcellular loc.
—
0.00
Isoforms (metab/obesity)
—
0.00
Механизм действия (21 полей)
Экспрессия (8 полей)
Tissue expression
—
0.00
In vitro
17β-HSD10 inhibition assay (IC50 determination)
0.90
In vivo
—
0.00
In silico
—
0.00
Genetic association
—
0.00
Ex vivo
—
0.00
Animal model
—
0.00
Diet/model
—
0.00