The Genetic Mosaic of Depression: Linking Polymorphisms to Neuroplasticity and Stress Regulation.
📄 Abstract
The origins of major depressive disorder (MDD) are complex, involving both environmental influences and a substantial genetic contribution. Genetic polymorphisms have been implicated in modulating susceptibility, disease course, and treatment response, yet findings are often modest, population-dependent, and sometimes inconsistent. This narrative review synthesizes current evidence on genetic variants associated with MDD, highlighting well-replicated results while distinguishing exploratory or emerging findings. Key systems reviewed include serotonergic (
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Идентификация (6 полей)
Механизм действия (21 полей)
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Genetic association
The context describes genetic association studies for major depressive disorder (MDD), including polymorphisms in serotonergic system, MC4R gene variant (rs17782313), and GWAS-identified loci.
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The context mentions a study on the interaction between MC4R gene variant and dominant dietary patterns on depression in obese and overweight women.
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Клиника (11 полей)
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