Seven days of warm-water immersion enhances resting irisin and BDNF, but not klotho, in older men.
📄 Abstract
We examined whether seven consecutive days of warm-water immersion could elevate resting and exercise-induced levels of brain-derived neurotrophic factor (BDNF), irisin and klotho in older adults. These biomarkers support cognitive and metabolic health, but their levels decline with age. Passive heat exposure, like warm-water immersion, may offer a promising alternative to exercise for enhancing cellular-level physiological resilience in populations where exercise is limited. Twelve habitually active older men (median [IQR] age: 68 [64-73] years;
Confidence:
0.22
· 9 полей извлечено
Идентификация (6 полей)
Target
irisin
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Alt. target
fibronectin type III domain-containing protein 5
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Protein family
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Functional class
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Subcellular loc.
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Isoforms (metab/obesity)
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Механизм действия (21 полей)
Mechanism
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Mutations (obesity/lean)
FTO rs9939609, MC4R rs17782313
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Activity (obesity)
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Activity temporal
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Energy balance
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Appetite
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Fat metabolism
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Lipolysis
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Thermogenesis
Reduced contextually induced muscle thermogenesis in rats with monogenic obesity
0.80
Muscle metabolism
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Inflammation
Modulator of adipose tissue IL-33 and regulatory T cells
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Glucose metabolism
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AA metabolism
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Hormonal pathways
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Cell death
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Adipocyte fibrosis
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Upstream (biochem)
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Upstream (physiol)
Warm-water immersion (passive heat exposure), Exercise
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Downstream (biochem)
BDNF, IL-33
0.80
Downstream (physiol)
Regulatory T cells
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PTMs
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Экспрессия (8 полей)
Tissue expression
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In vitro
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In vivo
Seven days of warm-water immersion enhances resting irisin and BDNF, but not klotho, in older men.
0.90
In silico
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Genetic association
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Ex vivo
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Animal model
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Diet/model
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