Transcriptomics-Guided Outcome Prediction (T-GOP) for Ecotoxicity Assessment: A Proof-of-Concept Study of PFOS Alternative OBS Disrupting Zebrafish Neurotransmitter Homeostasis and Cognition.
📄 Abstract
Transcriptomics provides mechanistic insights into chemical toxicity and serves as a hypothesis-generating tool for prioritizing potential adverse outcomes. Here, we introduced a transcriptomics-guided outcome prediction (T-GOP) framework, a hypothesis-informed approach that uses transcriptomic enrichment to prioritize end points for targeted experimental validation. As a case study, the ecotoxicological effects of the PFOS alternative, sodium
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Идентификация (6 полей)
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Механизм действия (21 полей)
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Экспрессия (8 полей)
Tissue expression
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In vivo
Zebrafish (Danio rerio) embryo-larval stages
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Transcriptomics-guided outcome prediction (T-GOP) framework
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Animal model
Zebrafish (Danio rerio)
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Клиника (11 полей)
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