Nanopiezoelectric 3D-Bioprinted Neural Organoid Models Epileptic Neuron-Microglia Circuit in Neurodegeneration.
📄 Abstract
Epilepsy is increasingly linked to neurodegeneration, yet the cellular drivers of the neuron-microglia interplay remain unclear. Herein, we present "EpiNeuroid", a 3D-bioprinted human neural organoid that incorporates barium titanate piezoelectric nanoparticles to generate an on-demand, ultrasound-triggered electrostimulatory microenvironment that induces a hyperexcitable state, recapitulating key electrophysiological signatures indicative of a trend toward epileptiform discharges. EpiNeuroid recapitulates neuronal DAMPs release (HMGB1, TLR4, NF-κB), microglial activation (Iba1, TNF-α, IL-1β, IL-6, iNOS), heightened neuronal Ca
Confidence:
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Идентификация (6 полей)
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EpiNeuroid (3D-bioprinted human neural organoid with barium titanate piezoelectric nanoparticles for ultrasound-triggered electrostimulation)
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