A pharmacological rat model of recurrent pelvic pain exhibiting hyperalgesia and depression-like behaviors.
📄 Abstract
Primary dysmenorrhea (PDM) involves recurrent pelvic pain (RPP), alongside menstruation and psychological comorbidity, yet existing models inadequately capture its recurrent nature. In this study, we established a pharmacologically induced rat model of RPP, using estradiol benzoate and oxytocin over six 4-day cycles. The RPP model produced robust and sustained writhing responses, with writhing latency dropping from 30 to 4 min (
Confidence:
0.09
· 3 полей извлечено
Идентификация (6 полей)
Механизм действия (21 полей)
Mechanism
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Mutations (obesity/lean)
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Activity (obesity)
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Activity temporal
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Energy balance
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Appetite
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Fat metabolism
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Lipolysis
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Thermogenesis
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Muscle metabolism
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Inflammation
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Glucose metabolism
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AA metabolism
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Hormonal pathways
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Cell death
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Adipocyte fibrosis
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Upstream (biochem)
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Upstream (physiol)
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Downstream (biochem)
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Downstream (physiol)
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PTMs
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Экспрессия (8 полей)
Tissue expression
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In vitro
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In vivo
pharmacologically induced rat model of recurrent pelvic pain using estradiol benzoate and oxytocin over six 4-day cycles
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In silico
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Genetic association
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Ex vivo
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Animal model
rat
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Diet/model
pharmacologically induced recurrent pelvic pain model
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