Nobiletin Ameliorates Alzheimer's Disease Pathology by Reducing Oxidative Stress and Neuroinflammation Through the AMPK/SIRT1/PGC-1
Confidence:
0.09
· 3 полей извлечено
Идентификация (6 полей)
Механизм действия (21 полей)
Mechanism
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Mutations (obesity/lean)
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Activity (obesity)
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Activity temporal
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Energy balance
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Appetite
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Fat metabolism
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Lipolysis
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Thermogenesis
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Muscle metabolism
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Inflammation
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Glucose metabolism
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AA metabolism
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Hormonal pathways
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Cell death
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Adipocyte fibrosis
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Upstream (biochem)
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Upstream (physiol)
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Downstream (biochem)
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Downstream (physiol)
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PTMs
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Экспрессия (8 полей)
Tissue expression
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In vitro
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In vivo
Nobiletin ameliorates Alzheimer's disease pathology in mouse models; STZ-induced Alzheimer's disease mouse model; scopolamine + heavy metal mixture-induced Alzheimer's disease rat model
0.90
In silico
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Genetic association
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Ex vivo
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Animal model
Mouse models of Alzheimer's disease; STZ-induced Alzheimer's disease mouse model; scopolamine + heavy metal mixture-induced Alzheimer's disease rat model
0.90
Diet/model
STZ-induced Alzheimer's disease; scopolamine + heavy metal mixture-induced Alzheimer's disease
0.90