Synergistic Therapeutic Effects of Tetrahydroberberine Combined with Protopanaxadiol on PCPA-Induced Insomnia in Rats: Involvement of the Microbiota-Gut-Brain Axis and Regulation of PI3K/AKT/AGE-RAGE Pathways.
Confidence:
0.09
· 4 полей извлечено
Идентификация (6 полей)
Механизм действия (21 полей)
Mechanism
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Mutations (obesity/lean)
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Activity (obesity)
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Activity temporal
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Energy balance
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Appetite
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Fat metabolism
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Lipolysis
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Thermogenesis
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Muscle metabolism
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Inflammation
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Glucose metabolism
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AA metabolism
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Hormonal pathways
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Cell death
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Adipocyte fibrosis
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Upstream (biochem)
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Upstream (physiol)
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Downstream (biochem)
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Downstream (physiol)
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PTMs
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Экспрессия (8 полей)
Tissue expression
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In vitro
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In vivo
PCPA-induced insomnia in rats; insulin-resistance-induced Alzheimer's disease rat model; vascular dementia rats; Parkinson's disease model; Bupleuri Radix study in rats
0.90
In silico
in-silico insights from demethyleneberberine study
0.80
Genetic association
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Ex vivo
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Animal model
rats
0.90
Diet/model
PCPA-induced insomnia; insulin-resistance-induced Alzheimer's disease; vascular dementia; Parkinson's disease; Bupleuri Radix study
0.90
Клиника (11 полей)
Drug
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Indication
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Off-target
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Trial stage
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Pharma competitors
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AE severity
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MOA weight loss
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Endpoints
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Approved
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