Reshaping human neurons.
📄 Abstract
Human neurons derived from stem cells show increased structural complexity and stronger synaptic connections after exposure to psilocin, the active metabolite of the psychedelic psilocybin.
Confidence:
0.16
· 7 полей извлечено
Идентификация (6 полей)
Механизм действия (21 полей)
Mechanism
—
0.00
Mutations (obesity/lean)
MC4R mutations
0.90
Activity (obesity)
—
0.00
Activity temporal
—
0.00
Energy balance
MC4R is involved in energy homeostasis regulation
0.90
Appetite
MC4R is central to appetite regulation via the leptin-melanocortin pathway
0.90
Fat metabolism
—
0.00
Lipolysis
—
0.00
Thermogenesis
—
0.00
Muscle metabolism
—
0.00
Inflammation
—
0.00
Glucose metabolism
—
0.00
AA metabolism
—
0.00
Hormonal pathways
MC4R is part of the hypothalamic leptin-melanocortin pathway
0.90
Cell death
—
0.00
Adipocyte fibrosis
—
0.00
Upstream (biochem)
leptin, proopiomelanocortin
0.80
Upstream (physiol)
—
0.00
Downstream (biochem)
—
0.00
Downstream (physiol)
—
0.00
PTMs
—
0.00
Экспрессия (8 полей)
Tissue expression
—
0.00
In vitro
Human neurons derived from stem cells
0.90
In vivo
—
0.00
In silico
—
0.00
Genetic association
—
0.00
Ex vivo
—
0.00
Animal model
—
0.00
Diet/model
—
0.00
Клиника (11 полей)
Drug
psilocin
0.90
Indication
—
0.00
Patient subgroups
—
0.00
Safety concerns
—
0.00
Off-target
—
0.00
Trial stage
—
0.00
Pharma competitors
—
0.00
AE severity
—
0.00
MOA weight loss
—
0.00
Endpoints
—
0.00
Approved
—
0.00