🧬 BDNF Extraction Viewer

Извлечено: 997 / 997 (100.0%) Средняя confidence: 0.13
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The protein RAB5IF promotes BDNF signaling by stimulating the SUMOylation of Gα

PMID: 41915731 · DOI: 10.1126/scisignal.aec8898 · Science signaling, 2026 · Xin Shi, Han-Qi Liu, Shi-Zhong Cai, Yi-Hang Shen, Jin-Long Chai, Mei-Qing Zhang, Chen-Yang Xu, Zhi-Qing Zhang, John Mars
📄 Abstract

Chronic stress and impaired signaling by the neurotrophic factor BDNF are associated with depression. The heterotrimeric G protein subunits Gα

Confidence: 0.02 · 1 полей извлечено
Идентификация (6 полей)
Target
RAB5IF
0.90
Alt. target
0.00
Protein family
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Functional class
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Subcellular loc.
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Isoforms (metab/obesity)
0.00
Механизм действия (21 полей)
Mechanism
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Mutations (obesity/lean)
0.00
Activity (obesity)
0.00
Activity temporal
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Energy balance
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Appetite
0.00
Fat metabolism
0.00
Lipolysis
0.00
Thermogenesis
0.00
Muscle metabolism
0.00
Inflammation
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Glucose metabolism
0.00
AA metabolism
0.00
Hormonal pathways
0.00
Cell death
0.00
Adipocyte fibrosis
0.00
Upstream (biochem)
0.00
Upstream (physiol)
0.00
Downstream (biochem)
0.00
Downstream (physiol)
0.00
PTMs
0.00
Экспрессия (8 полей)
Tissue expression
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In vitro
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In vivo
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In silico
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Genetic association
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Ex vivo
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Animal model
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Diet/model
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Клиника (11 полей)
Drug
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Indication
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Patient subgroups
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Safety concerns
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Off-target
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Trial stage
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Pharma competitors
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AE severity
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MOA weight loss
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Endpoints
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Approved
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