BDNF Extraction Viewer

Fibronectin type III domain-containing protein 5/irisin in extracellular vesicles is reduced in older individuals.

PMID: 41940186 · DOI: 10.1093/braincomms/fcag085 · Brain communications, 2026 · Tai R Hunter, Natalia M Lyra E Silva, Guilherme B de Freitas, Tayna Rody, Luis E Santos, Jieming Zhang, Alexis Bullock,

📄 Abstract

The progressive accumulation of physiological stress as we age, known as allostatic load, is linked to an increased risk of dementia. Fostering brain resilience through physical exercise can counteract allostatic load and improve adaptation to age-related brain alterations. Fibronectin type III domain-containing protein 5 (FNDC5)/irisin is a neuroprotective exercise-linked hormone found in extracellular vesicles (EV-FNDC5/irisin). Here, we sought to analyse EV-FNDC5/irisin in ageing as a promising biomarker of brain resilience. We measured exercise-associated factors, including EV-FNDC5/irisin, brain-derived neurotrophic factor (BDNF), and cathepsin B in the serum of 31 young (18-28 years) and 19 older subjects (65-79 years). Levels of FNDC5/irisin in serum-derived EVs are markedly reduced in older subjects compared to young (

Confidence: 0.23 · 12 полей извлечено

Идентификация (6 полей)

Target

Fibronectin type III domain-containing protein 5

1.00

Alt. target

irisin

1.00

Protein family

Fibronectin type III domain-containing protein family

0.90

Functional class

—

0.00

Subcellular loc.

extracellular vesicles

0.90

Isoforms (metab/obesity)

—

0.00

Механизм действия (21 полей)

Mechanism

—

0.00

Mutations (obesity/lean)

—

0.00

Activity (obesity)

—

0.00

Activity temporal

—

0.00

Energy balance

Regulates brain energy homeostasis

0.80

Appetite

—

0.00

Fat metabolism

—

0.00

Lipolysis

—

0.00

Thermogenesis

—

0.00

Muscle metabolism

Released during muscle contraction

0.90

Inflammation

Reduces vascular inflammation

0.70

Glucose metabolism

—

0.00

AA metabolism

—

0.00

Hormonal pathways

Exercise-linked hormone; endocrine signaling molecule in muscle-brain axis

0.90

Cell death

—

0.00

Adipocyte fibrosis

—

0.00

Upstream (biochem)

—

0.00

Upstream (physiol)

Physical exercise; aerobic exercise

0.90

Downstream (biochem)

Brain-derived neurotrophic factor (BDNF); cathepsin B

0.70

Downstream (physiol)

Improved endothelial function; reduced atherosclerosis; neuroprotection; brain resilience

0.80

PTMs

—

0.00

Экспрессия (8 полей)

Tissue expression

—

0.00

In vitro

—

0.00

In vivo

Measured EV-FNDC5/irisin, BDNF, and cathepsin B in serum of 31 young (18-28 years) and 19 older subjects (65-79 years).

0.90

In silico

—

0.00

Genetic association

—

0.00

Ex vivo

—

0.00

Animal model

—

0.00

Diet/model

—

0.00

Клиника (11 полей)

Drug

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0.00

Indication

—

0.00

Patient subgroups

—

0.00

Safety concerns

—

0.00

Off-target

—

0.00

Trial stage

—

0.00

Pharma competitors

—

0.00

AE severity

—

0.00

MOA weight loss

—

0.00

Endpoints

—

0.00

Approved

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0.00