Brain-derived neurotrophic factor coordinates neuron-intrinsic programs to enhance axonal regeneration in human motor neurons.
📄 Abstract
The cell-intrinsic capacity of neurons to regenerate axons requires widespread coordination of the transcriptome, activation of multiple kinases, and reorganization of the cytoskeleton. Axonal repair is also influenced by extrinsic activating factors, such as neurotrophins. Here, we found that the neurotrophin BDNF amplifies multiple neuron-intrinsic programs to foster axonal regeneration in human iPSC-derived lower motor neurons (i
Confidence:
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· 4 полей извлечено
Идентификация (6 полей)
Target
Brain-derived neurotrophic factor
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Alt. target
BDNF
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Protein family
Neurotrophin
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Subcellular loc.
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Механизм действия (21 полей)
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Экспрессия (8 полей)
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In vitro
human iPSC-derived lower motor neurons
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Клиника (11 полей)
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