Exercise-induced GPLD1 is associated with neuroprotection and improvement of hippocampal dysfunction in an Alzheimer's disease model.
📄 Abstract
This study investigated the therapeutic potential of exercise training and the associated role of Glycosylphosphatidylinositol-specific phospholipase D1 (GPLD1) in an experimental Alzheimer’s disease (AD) model. Using a D-galactose/AlCl [Image: see text]
Confidence:
0.13
· 5 полей извлечено
Идентификация (6 полей)
Target
Glycosylphosphatidylinositol-specific phospholipase D1
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Alt. target
GPLD1
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Protein family
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Functional class
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Subcellular loc.
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Isoforms (metab/obesity)
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Механизм действия (21 полей)
Mechanism
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Mutations (obesity/lean)
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Activity (obesity)
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Activity temporal
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Energy balance
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Appetite
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Fat metabolism
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Lipolysis
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Thermogenesis
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Muscle metabolism
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Inflammation
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Glucose metabolism
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AA metabolism
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Hormonal pathways
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Cell death
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Adipocyte fibrosis
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Upstream (biochem)
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Upstream (physiol)
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Downstream (biochem)
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Downstream (physiol)
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PTMs
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Экспрессия (8 полей)
Tissue expression
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In vitro
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In vivo
Exercise training in an experimental Alzheimer's disease model (D-galactose/AlCl3) to investigate GPLD1 role
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In silico
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Genetic association
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Ex vivo
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Animal model
D-galactose/AlCl3-induced Alzheimer's disease model
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Diet/model
D-galactose/AlCl3
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