A Novel Probiotic
📄 Abstract
Cognitive impairment is acknowledged as an early stage between normal aging and Alzheimer's disease, emphasizing the need for prompt intervention. There is growing evidence that the gut-brain axis plays a role in regulating cognitive function, indicating that probiotics and their derivatives may impact cognitive functions through the brain-gut axis. In this study, we isolated and identified a novel bacterial strain
Confidence:
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Идентификация (6 полей)
Target
dual-specificity phosphatase 6
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Alt. target
Dusp6
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Protein family
dual-specificity phosphatase
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Functional class
phosphatase
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Subcellular loc.
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Isoforms (metab/obesity)
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Механизм действия (21 полей)
Mechanism
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Mutations (obesity/lean)
Loss-of-function mutations in ADCY3 cause monogenic severe obesity
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Activity (obesity)
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Activity temporal
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Energy balance
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Appetite
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Fat metabolism
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Lipolysis
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Thermogenesis
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Muscle metabolism
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Inflammation
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Glucose metabolism
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AA metabolism
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Hormonal pathways
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Cell death
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Adipocyte fibrosis
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Upstream (biochem)
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Upstream (physiol)
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Downstream (biochem)
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Downstream (physiol)
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PTMs
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Экспрессия (8 полей)
Tissue expression
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In vitro
in vitro characterization of probiotic properties of isolated and grown co-cultures on halophyte-based substrate
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In vivo
Impact of chronic consumption of probiotics, oats, and apples on expression of genes related to bile acids, lipid, gut peptides, and inflammation in peripheral monocular cells - findings from the CABALA study
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In silico
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Genetic association
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Ex vivo
Genomic analysis in the colon tissues of omega-3 fatty acid-treated rats identifies novel gene signatures implicated in ulcerative colitis
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Animal model
Unique Gene Expression Signatures in the Intestinal Mucosa and Organoids Derived from Germ-Free and Monoassociated Mice
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Diet/model
Impact of chronic consumption of probiotics, oats, and apples on expression of genes related to bile acids, lipid, gut peptides, and inflammation in peripheral monocular cells - findings from the CABALA study
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Клиника (11 полей)
Drug
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Indication
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Patient subgroups
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Safety concerns
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Off-target
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Trial stage
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Pharma competitors
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AE severity
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MOA weight loss
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Approved
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