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Differential DNA Methylation of the Brain-Derived Neurotrophic Factor Gene is Observed after Pediatric Traumatic Brain Injury Compared with Orthopedic Injury.

PMID: 41376515 · DOI: 10.1177/08977151251400737 · Journal of neurotrauma, 2025 · Lacey W Heinsberg, Aboli Kesbhat, Bailey Petersen, Lauren Kaseman, Zachary Stec, Nivinthiga Anton, Patrick M Kochanek, K
📄 Abstract

Pediatric traumatic brain injury (TBI) triggers biological changes that may differ from those observed in non-brain injuries. Brain-derived neurotrophic factor (

Confidence: 0.04 · 2 полей извлечено
Идентификация (6 полей)
Target
Brain-derived neurotrophic factor
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Alt. target
BDNF
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Protein family
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Subcellular loc.
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Isoforms (metab/obesity)
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Механизм действия (21 полей)
Mechanism
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Activity (obesity)
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Activity temporal
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Energy balance
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Appetite
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Fat metabolism
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Lipolysis
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Thermogenesis
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Muscle metabolism
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Inflammation
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Glucose metabolism
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AA metabolism
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Hormonal pathways
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Cell death
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Adipocyte fibrosis
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Upstream (biochem)
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Upstream (physiol)
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Downstream (biochem)
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Downstream (physiol)
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PTMs
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Экспрессия (8 полей)
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Клиника (11 полей)
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MOA weight loss
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