BDNF genotype and cognition in older adults with breast cancer and healthy controls in the Thinking and Living with Cancer Study.
Confidence:
0.12
· 6 полей извлечено
Идентификация (6 полей)
Target
BDNF
1.00
Alt. target
brain-derived neurotrophic factor
1.00
Protein family
neurotrophin
0.90
Functional class
growth factor
0.90
Subcellular loc.
—
0.00
Isoforms (metab/obesity)
—
0.00
Механизм действия (21 полей)
Mechanism
—
0.00
Mutations (obesity/lean)
—
0.00
Activity (obesity)
—
0.00
Activity temporal
—
0.00
Energy balance
—
0.00
Appetite
—
0.00
Fat metabolism
—
0.00
Lipolysis
—
0.00
Thermogenesis
—
0.00
Muscle metabolism
—
0.00
Inflammation
—
0.00
Glucose metabolism
—
0.00
AA metabolism
—
0.00
Hormonal pathways
—
0.00
Cell death
—
0.00
Adipocyte fibrosis
—
0.00
Upstream (biochem)
—
0.00
Upstream (physiol)
—
0.00
Downstream (biochem)
—
0.00
Downstream (physiol)
—
0.00
PTMs
—
0.00
Экспрессия (8 полей)
Tissue expression
—
0.00
In vitro
—
0.00
In vivo
—
0.00
In silico
—
0.00
Genetic association
BDNF Val66Met variant associated with cognition in breast cancer patients and healthy controls; BDNF genotype associated with cognition in older adults with breast cancer; genetic variants associated with longitudinal cognitive performance in older breast cancer patients and controls; menstrual cycle modulates effect of BDNF Val66Met variant on category learning
0.90
Ex vivo
—
0.00
Animal model
—
0.00
Diet/model
acute oyster mushroom intervention in healthy older adults
0.80
Клиника (11 полей)
Drug
—
0.00
Indication
—
0.00
Patient subgroups
—
0.00
Safety concerns
—
0.00
Off-target
—
0.00
Trial stage
—
0.00
Pharma competitors
—
0.00
AE severity
—
0.00
MOA weight loss
—
0.00
Endpoints
—
0.00
Approved
—
0.00