NGF/BDNF-Trk/p75NTR signaling in osteosarcoma immunity: biomarkers and therapeutic opportunities.
📄 Abstract
Osteosarcoma is a primary bone malignancy in which outcomes for patients with metastatic or relapsed disease remain unsatisfactory despite optimized surgery-chemotherapy backbones. Recently, advances in cancer neuroscience have highlighted neurotrophins-nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF)-and their Trk/p75
Confidence:
0.1
· 4 полей извлечено
Идентификация (6 полей)
Target
NGF/BDNF-Trk/p75NTR
0.90
Alt. target
NGF/TrkA and BDNF/TrkB
0.80
Protein family
neurotrophins and their receptors
0.90
Functional class
growth factor signaling
0.80
Subcellular loc.
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0.00
Isoforms (metab/obesity)
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0.00
Механизм действия (21 полей)
Mechanism
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Mutations (obesity/lean)
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Activity (obesity)
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0.00
Activity temporal
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Energy balance
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0.00
Appetite
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0.00
Fat metabolism
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0.00
Lipolysis
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0.00
Thermogenesis
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0.00
Muscle metabolism
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0.00
Inflammation
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0.00
Glucose metabolism
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0.00
AA metabolism
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0.00
Hormonal pathways
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0.00
Cell death
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0.00
Adipocyte fibrosis
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0.00
Upstream (biochem)
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0.00
Upstream (physiol)
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0.00
Downstream (biochem)
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0.00
Downstream (physiol)
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0.00
PTMs
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0.00
Экспрессия (8 полей)
Tissue expression
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In vitro
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In vivo
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In silico
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Genetic association
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Ex vivo
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Animal model
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Diet/model
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