Crocetin as a Neuroprotective Agent: Targeting Western Diet-Induced Cognitive Dysfunction Through Antioxidant, Anti-Inflammatory and Gut-Brain Axis Modulation.
📄 Abstract
Western diet-induced cognitive dysfunction is a rapidly emerging health challenge driven by excessive intake of high-fat, high-sugar, and ultra-processed foods. These dietary patterns promote neuroinflammation, oxidative stress, insulin resistance, gut dysbiosis, and blood-brain barrier (BBB) disruption, ultimately leading to synaptic dysfunction and cognitive decline. Crocetin, an apocarotenoid derived from saffron and
Confidence:
0.15
· 8 полей извлечено
Идентификация (6 полей)
Target
Crocetin
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Alt. target
CRT
0.80
Protein family
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Functional class
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Subcellular loc.
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Isoforms (metab/obesity)
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Механизм действия (21 полей)
Mechanism
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Activity (obesity)
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Activity temporal
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Energy balance
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Fat metabolism
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Lipolysis
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Thermogenesis
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Muscle metabolism
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Inflammation
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Glucose metabolism
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AA metabolism
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Hormonal pathways
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Cell death
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Adipocyte fibrosis
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Upstream (biochem)
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Upstream (physiol)
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Downstream (physiol)
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Экспрессия (8 полей)
Tissue expression
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In vitro
N2a/APP cells
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In vivo
rats
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In silico
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Genetic association
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Ex vivo
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Animal model
rats
0.90
Diet/model
Western diet
0.90
Клиника (11 полей)
Drug
Crocetin
0.90
Indication
Western diet-induced cognitive dysfunction
0.90
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Off-target
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Trial stage
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MOA weight loss
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Approved
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