Fasted-State Aerobic Exercise Enhances Cognition and Hippocampal BDNF Signaling in an Alzheimer's Disease Rat Model.
📄 Abstract
Alzheimer's disease (AD) is a multifactorial disorder that demands a comprehensive management strategy. Both aerobic exercise training and intermittent fasting (IF) have been shown to ameliorate AD symptoms, yet the impact of exercise in the fasted state remains understudied. This study compared the effects of four weeks of moderate‑intensity treadmill running in either a fasted or a normal fed state on cognitive function and hippocampal BDNF signaling in an amyloid-β (Aβ)
Confidence:
0.18
· 7 полей извлечено
Идентификация (6 полей)
Target
BDNF
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Alt. target
Brain-Derived Neurotrophic Factor
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Protein family
Neurotrophin
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Functional class
Growth factor
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Subcellular loc.
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Isoforms (metab/obesity)
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Механизм действия (21 полей)
Mechanism
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Mutations (obesity/lean)
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Activity (obesity)
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Activity temporal
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Energy balance
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Appetite
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Fat metabolism
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Lipolysis
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Thermogenesis
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Muscle metabolism
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Inflammation
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Glucose metabolism
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AA metabolism
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Hormonal pathways
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Cell death
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Adipocyte fibrosis
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Upstream (biochem)
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Upstream (physiol)
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Downstream (biochem)
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Downstream (physiol)
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PTMs
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Экспрессия (8 полей)
Tissue expression
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In vitro
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In vivo
Fasted-state aerobic exercise enhances cognition and hippocampal BDNF signaling in an Alzheimer's disease rat model
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In silico
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Genetic association
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Ex vivo
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Animal model
Alzheimer's disease rat model
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Diet/model
fasted state vs normal fed state
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