Negr1 Deficiency Modulates Sex-Specific Neurobehavioral Adaptations to Social Isolation.
Confidence:
0.18
· 7 полей извлечено
Идентификация (6 полей)
Target
Negr1
0.90
Alt. target
neuronal growth regulator 1
0.90
Protein family
—
0.00
Functional class
—
0.00
Subcellular loc.
—
0.00
Isoforms (metab/obesity)
—
0.00
Механизм действия (21 полей)
Mechanism
—
0.00
Mutations (obesity/lean)
NEGR1, Adcy3
0.90
Activity (obesity)
—
0.00
Activity temporal
—
0.00
Energy balance
—
0.00
Appetite
—
0.00
Fat metabolism
—
0.00
Lipolysis
—
0.00
Thermogenesis
Reduced contextually induced muscle thermogenesis in monogenic obesity
0.80
Muscle metabolism
—
0.00
Inflammation
—
0.00
Glucose metabolism
—
0.00
AA metabolism
—
0.00
Hormonal pathways
—
0.00
Cell death
—
0.00
Adipocyte fibrosis
—
0.00
Upstream (biochem)
—
0.00
Upstream (physiol)
—
0.00
Downstream (biochem)
—
0.00
Downstream (physiol)
—
0.00
PTMs
—
0.00
Экспрессия (8 полей)
Tissue expression
—
0.00
In vitro
—
0.00
In vivo
Negr1 knockout mice; maternal separation in rats; fear conditioning in rats
0.90
In silico
—
0.00
Genetic association
—
0.00
Ex vivo
—
0.00
Animal model
mice; rats
0.90
Diet/model
social isolation; maternal separation; fear conditioning
0.90