Elevated Copper Level in Schizophrenia Results in Neurotransmitter and Cognitive Alteration.
Confidence:
0.11
· 5 полей извлечено
Идентификация (6 полей)
Механизм действия (21 полей)
Mechanism
—
0.00
Mutations (obesity/lean)
—
0.00
Activity (obesity)
—
0.00
Activity temporal
—
0.00
Energy balance
—
0.00
Appetite
—
0.00
Fat metabolism
—
0.00
Lipolysis
—
0.00
Thermogenesis
—
0.00
Muscle metabolism
—
0.00
Inflammation
—
0.00
Glucose metabolism
—
0.00
AA metabolism
—
0.00
Hormonal pathways
—
0.00
Cell death
—
0.00
Adipocyte fibrosis
—
0.00
Upstream (biochem)
—
0.00
Upstream (physiol)
—
0.00
Downstream (biochem)
—
0.00
Downstream (physiol)
—
0.00
PTMs
—
0.00
Экспрессия (8 полей)
Tissue expression
—
0.00
In vitro
Knockdown of mental disorder susceptibility genes disrupts neuronal network physiology in vitro
0.90
In vivo
Chronic copper exposure causes spatial memory impairment in mice; Vitamin D alleviates cognitive dysfunction induced by copper sulfate in rats
0.90
In silico
—
0.00
Genetic association
Elevated copper level in schizophrenia; BDNF gene mentioned
0.70
Ex vivo
—
0.00
Animal model
Mice; Rats
0.90
Diet/model
Copper exposure; Copper sulfate intake
0.90
Клиника (11 полей)
Drug
—
0.00
Indication
—
0.00
Patient subgroups
—
0.00
Safety concerns
—
0.00
Off-target
—
0.00
Trial stage
—
0.00
Pharma competitors
—
0.00
AE severity
—
0.00
MOA weight loss
—
0.00
Endpoints
—
0.00
Approved
—
0.00